![]() It provides the opportunity to identify the prevalence of, and factors related to, nocturnal asthma symptom(s) requiring albuterol (NASRA), as well as clinically important events linked to these symptoms. The Pediatric Asthma Controller Trial (PACT) was a 48-week long randomized clinical trial involving 6–14 year old children with mild to moderate persistent asthma that incorporated measures to enhance and monitor medication adherence 17. ![]() Fuhlbrigge and coworkers have also shown that the number of nocturnal awakenings over a 4-week period was associated with future asthma-related events (emergency department visits, hospitalizations or oral steroid bursts) 16. The authors concluded that nocturnal awakening may affect these outcomes, but were not able to examine associations over time due to the cross-sectional design 12. One cross-sectional study examined the consequences of nocturnal asthma on school attendance, school performance, and parents’ work attendance, using parent report for both awakening and morbidity in the 4 weeks before interviews. Studies in children have examined the prevalence of nocturnal asthma 6– 11, associations with nocturnal asthma and sleep quality 10 and other factors associated with nocturnal asthma 9, 12– 15, but all of these studies were of short duration (≤7 days) or cross-sectional. Although these nocturnal events are considered important in childhood asthma, their significance remains unclear due to a paucity of literature regarding this topic, in part due to the fact that most publications investigating nocturnal asthma have focused on adults (e.g., 2– 5). ![]() The frequency of nocturnal awakenings is used to categorize asthma severity and control based on expert opinion consensus 1. ![]()
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